Academic Calendar - 2020 ARCHIVE
Western University Academic Calendar. - 2020ARCHIVE
Biochemistry
An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s): Biochemistry 2288A.
Prerequisite(s): Either Biology 1001A or Biology 1201A and either Biology 1002B or Biology 1202B; Chemistry 1301A/B and Chemistry 1302A/B. Integrated Science 1001X can be used as a prerequisite in place of Biology 1002B and Chemistry 1302A/B.
Extra Information: 3 lecture hours. Note: It is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B or Chemistry 2273A).
Course Weight: 0.50
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An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s): Biochemistry 2280A.
Prerequisite(s): Chemistry 1301A/B and Chemistry 1302A/B; Biology 1290B; and registration in senior years of Foods and Nutrition modules.
Extra Information: 3 lecture hours. Note: It is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B or Chemistry 2273A).
Course Weight: 0.50
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This course consists of a series of laboratory exercises designed to familiarize the student with the basic methods in biochemistry and molecular biology, and to demonstrate concepts taught in biochemistry lecture courses. Students will learn how to present their results in an acceptable scientific format.
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 3 laboratory hours, 1 tutorial hour.
Course Weight: 0.50
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A consideration of the structure of proteins and nucleic acids; enzymology; elements of recombinant DNA technology and related methodology.
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or Biochemistry 2288A; a minimum mark of 60% in either Chemistry 2213A/B or Chemistry 2273A; and a minimum mark of 60% in either Chemistry 2223B or Chemistry 2283G.
Extra Information: 3 lecture hours, 1 tutorial hour.
Course Weight: 0.50
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Among the topics discussed will be principles of metabolic control, mechanisms of signal transduction, regulation of DNA replication, regulation of gene expression, and epigenetic mechanisms of gene regulation.
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or Biochemistry 2288A; a minimum mark of 60% in either Chemistry 2213A/B or Chemistry 2273A; and a minimum mark of 60% in either Chemistry 2223B or Chemistry 2283G.
Extra Information: 3 lecture hours, 1 tutorial hour.
Course Weight: 0.50
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Students carry out a research project under the direction of a faculty member, gaining practical experience in a biochemistry research laboratory. Experimental design, critical thinking, and scientific communication will be emphasized, and students will develop skills at reading and reviewing primary scientific literature.
Prerequisite(s): Permission of the Department.
Pre-or Corequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 5 laboratory hours per week. Enrollment in this course is limited.
Course Weight: 0.50
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A course dealing with Biochemical aspects of the human condition. Topics in human disease, medical testing, and lifestyle will be considered in a clinical-case-oriented fashion. The emphasis will be on structural and metabolic issues related to carbohydrates, lipids, vitamins, minerals, nucleic acids and proteins.
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or Biochemistry 2288A.
Extra Information: 3 lecture hours.
Course Weight: 0.50
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The application of biochemical and molecular principles to the analytical components used to select, evaluate and interpret tests for clinical diseases. Also included will be discussions on the specialized instruments required. Students will gain understanding of the practice of clinical biochemistry, as one of the disciplines of laboratory medicine.
Prerequisite(s): Either Biochemistry 2280A or Biochemistry 2288A with a mark of at least 65%.
Extra Information: 3 lecture hours. Enrollment limited.
Course Weight: 0.50
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Students will explore the chemical and physical underpinnings of biochemical phenomena by solving practical, real-world, quantitative problems. Students will learn how to answer biochemical research questions by applying advanced experimental strategies and techniques, including methods in bioinformatics and the mining of biochemical databases.
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 2 lecture hours, 1 tutorial hour.
Course Weight: 0.50
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An introduction to the principles of synthetic biology. Students learn to retrieve and apply information from databases to design and model regulated biological circuits using standard components (Biobricks). Teams of students create, communicate, and defend original synthetic biology proposals.
Extra Information: 2 lecture hours, 1 tutorial hour.
Note: it is recommended that Science 3377A/B be taken either prior to or concurrently with Biochemistry 3392F/G.
Course Weight: 0.50
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The use of fundamental techniques in molecular biology and molecular genetics are illustrated using examples from the classic and current literature. Selected topics include eukaryotic gene cloning, transgenic animals, rational drug design, DNA replication and cell cycle regulation.
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 2 lecture hours.
Course Weight: 0.50
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This course will explore how metabolic pathways are currently being re-engineered in microorganisms to produce drugs that are otherwise difficult to manufacture. We will also investigate how drug targets are being identified using newly developed chemical genetic screening methods. The impact of both approaches on medicine will be evaluated.
Antirequisite(s): Chemistry 4415B.
Prerequisite(s): Either (Biochemistry 3381A and Biochemistry 3382A) or (Biochemistry 2280A and one of Chemistry 3393A/B or Chemistry 4493A/B).
Extra Information: 2 lecture hours per week, 1 hour bi-weekly tutorial session.
Cross-listed with Chemistry 4415B.
Course Weight: 0.50
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Topics to be considered at an advanced level will include: translation, folding and assembly, targeting, turnover, structure and motifs.
Prerequisite(s): Biochemistry 3381A.
Extra Information: 2 lecture hours, 1 tutorial hour.
Course Weight: 0.50
Return to top
The course will cover applied aspects of protein chemistry in biotechnology and protein design. Topics covered will include applications of modern analytical and biophysical techniques used in proteomics and related biochemical analyses, protein structure design, and antibody engineering.
Prerequisite(s): Biochemistry 4420A.
Extra Information: 2 lecture hours per week.
Course Weight: 0.50
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Mutation of specific human genes subverts normal cellular physiology creating characteristic alterations called ‘hallmarks’ that fuel the development of cancer. The underlying processes that alter cellular pathways and gene function will be discussed. Cancer models and molecular therapies will be related to the cancer hallmarks.
Antirequisite(s): Pathology 4450A.
Extra Information: 2 lecture hours
Cross-listed with Pathology 4450A.
Course Weight: 0.50
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The translation of cancer research discoveries into clinical practice, emphasizing critical thinking, research design, evaluation of data from the literature and ethics. Students will engage with community partners associated with cancer research, patient support and care, and will work on a team project relevant to the partners’ needs.
Prerequisite(s): Biochemistry 4450A.
Extra Information: 3 lecture/tutorial hours per week.
Course Weight: 0.50
Return to top
This course applies knowledge of biochemistry and molecular biology to the understanding of human diseases. Topics of current interest are used as examples to explore the molecular mechanisms by which disease states arise and how this knowledge can be used to design therapies.
Prerequisite(s): Biochemistry 3381A.
Extra Information: 2 lecture hours.
Course Weight: 0.50
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The major laboratory course for the Honours Specialization in Biochemistry and Honours Specialization modules combined with Biochemistry. Lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Antirequisite(s): Anatomy and Cell Biology 4480E, Chemical Biology 4500E, Medical Biophysics 4970E, Medical Sciences 4900F/G/Z, Microbiology and Immunology 4970E, Pathology 4980E, the former Pathology and Toxicology 4980E, the former Biochemistry 4485E.
Prerequisite(s): Biochemistry 3380G, Biochemistry 3381A and Biochemistry 3382A, with marks in each of at least 70%. Enrolment is limited, and is available only to students in Year 4 of Honours Specialization modules in Biochemistry, Biochemistry and Cell Biology, Biochemistry and Pathology of Human Disease, Biochemistry and Chemistry, Biochemistry of Infection and Immunity, Computational Biochemistry, and Medical Biophysics and Biochemistry. Students in the Honours Specialization in Biochemistry of Infection and Immunity may substitute one of Microbiology and Immunology 3610F, Microbiology and Immunology 3620G, with a minimum mark of 70% in lieu of Biochemistry 3380G as a prerequisite. Students in the Honours Specialization in Computational Biochemistry may substitute Biochemistry 3383F/G with a minimum mark of 70% in lieu of Biochemistry 3380G as a prerequisite.
Extra Information: 15 hours per week. Enrolment in this course is limited.
Course Weight: 1.50
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The major laboratory course for the Honours Specialization in Biochemistry and Cancer Biology. Lectures on safety, use of animals in research, scientific integrity; an independent cancer-related research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Antirequisite(s): Anatomy and Cell Biology 4480E, Biochemistry 4483E, Chemical Biology 4500E, Medical Biophysics 4970E, Medical Sciences 4900F/G/Z, Microbiology and Immunology 4970E, Pathology 4980E, the former Pathology and Toxicology 4980E.
Prerequisite(s): A mark of at least 70% in one of the following: Biochemistry 3380G, Microbiology and Immunology 3620G, Physiology and Pharmacology 3000E or the former Pharmacology 3580Z; and enrolment in Year 4 of the Honours Specialization in Biochemistry and Cancer Biology.
Extra Information: 15 hours per week, indicate lecture/tutorial/lab hours.
To be offered for the first time in 2018/19.
Course Weight: 1.50
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This laboratory course is intended for students interested in pursuing graduate-level research. Lectures on literature searches, data mining, and effective communication; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (introduction to topic, mid-year report, seminar).
Prerequisite(s): One of Biochemistry 4483E, Biochemistry 4486E, or the former Biochemistry 4485E, and permission of the department.
Extra Information: 12 laboratory hours per week and participation in the Biochemistry Graduate Seminar.
Course Weight: 1.00
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Biochemistry
An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s): Biochemistry 2288A.
Prerequisite(s): Either Biology 1001A or Biology 1201A and either Biology 1002B or Biology 1202B; Chemistry 1301A/B and Chemistry 1302A/B. Integrated Science 1001X can be used as a prerequisite in place of Biology 1002B and Chemistry 1302A/B.
Extra Information: 3 lecture hours. Note: It is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B or Chemistry 2273A).
Course Weight: 0.50
Return to top
An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s): Biochemistry 2280A.
Prerequisite(s): Chemistry 1301A/B and Chemistry 1302A/B; Biology 1290B; and registration in senior years of Foods and Nutrition modules.
Extra Information: 3 lecture hours. Note: It is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B or Chemistry 2273A).
Course Weight: 0.50
Return to top
This course consists of a series of laboratory exercises designed to familiarize the student with the basic methods in biochemistry and molecular biology, and to demonstrate concepts taught in biochemistry lecture courses. Students will learn how to present their results in an acceptable scientific format.
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 3 laboratory hours, 1 tutorial hour.
Course Weight: 0.50
Return to top
A consideration of the structure of proteins and nucleic acids; enzymology; elements of recombinant DNA technology and related methodology.
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or Biochemistry 2288A; a minimum mark of 60% in either Chemistry 2213A/B or Chemistry 2273A; and a minimum mark of 60% in either Chemistry 2223B or Chemistry 2283G.
Extra Information: 3 lecture hours, 1 tutorial hour.
Course Weight: 0.50
Return to top
Among the topics discussed will be principles of metabolic control, mechanisms of signal transduction, regulation of DNA replication, regulation of gene expression, and epigenetic mechanisms of gene regulation.
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or Biochemistry 2288A; a minimum mark of 60% in either Chemistry 2213A/B or Chemistry 2273A; and a minimum mark of 60% in either Chemistry 2223B or Chemistry 2283G.
Extra Information: 3 lecture hours, 1 tutorial hour.
Course Weight: 0.50
Return to top
Students carry out a research project under the direction of a faculty member, gaining practical experience in a biochemistry research laboratory. Experimental design, critical thinking, and scientific communication will be emphasized, and students will develop skills at reading and reviewing primary scientific literature.
Prerequisite(s): Permission of the Department.
Pre-or Corequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 5 laboratory hours per week. Enrollment in this course is limited.
Course Weight: 0.50
Return to top
A course dealing with Biochemical aspects of the human condition. Topics in human disease, medical testing, and lifestyle will be considered in a clinical-case-oriented fashion. The emphasis will be on structural and metabolic issues related to carbohydrates, lipids, vitamins, minerals, nucleic acids and proteins.
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or Biochemistry 2288A.
Extra Information: 3 lecture hours.
Course Weight: 0.50
Return to top
The application of biochemical and molecular principles to the analytical components used to select, evaluate and interpret tests for clinical diseases. Also included will be discussions on the specialized instruments required. Students will gain understanding of the practice of clinical biochemistry, as one of the disciplines of laboratory medicine.
Prerequisite(s): Either Biochemistry 2280A or Biochemistry 2288A with a mark of at least 65%.
Extra Information: 3 lecture hours. Enrollment limited.
Course Weight: 0.50
Return to top
Students will explore the chemical and physical underpinnings of biochemical phenomena by solving practical, real-world, quantitative problems. Students will learn how to answer biochemical research questions by applying advanced experimental strategies and techniques, including methods in bioinformatics and the mining of biochemical databases.
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 2 lecture hours, 1 tutorial hour.
Course Weight: 0.50
Return to top
An introduction to the principles of synthetic biology. Students learn to retrieve and apply information from databases to design and model regulated biological circuits using standard components (Biobricks). Teams of students create, communicate, and defend original synthetic biology proposals.
Extra Information: 2 lecture hours, 1 tutorial hour.
Note: it is recommended that Science 3377A/B be taken either prior to or concurrently with Biochemistry 3392F/G.
Course Weight: 0.50
Return to top
The use of fundamental techniques in molecular biology and molecular genetics are illustrated using examples from the classic and current literature. Selected topics include eukaryotic gene cloning, transgenic animals, rational drug design, DNA replication and cell cycle regulation.
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382A.
Extra Information: 2 lecture hours.
Course Weight: 0.50
Return to top
This course will explore how metabolic pathways are currently being re-engineered in microorganisms to produce drugs that are otherwise difficult to manufacture. We will also investigate how drug targets are being identified using newly developed chemical genetic screening methods. The impact of both approaches on medicine will be evaluated.
Antirequisite(s): Chemistry 4415B.
Prerequisite(s): Either (Biochemistry 3381A and Biochemistry 3382A) or (Biochemistry 2280A and one of Chemistry 3393A/B or Chemistry 4493A/B).
Extra Information: 2 lecture hours per week, 1 hour bi-weekly tutorial session.
Cross-listed with Chemistry 4415B.
Course Weight: 0.50
Return to top
Topics to be considered at an advanced level will include: translation, folding and assembly, targeting, turnover, structure and motifs.
Prerequisite(s): Biochemistry 3381A.
Extra Information: 2 lecture hours, 1 tutorial hour.
Course Weight: 0.50
Return to top
The course will cover applied aspects of protein chemistry in biotechnology and protein design. Topics covered will include applications of modern analytical and biophysical techniques used in proteomics and related biochemical analyses, protein structure design, and antibody engineering.
Prerequisite(s): Biochemistry 4420A.
Extra Information: 2 lecture hours per week.
Course Weight: 0.50
Return to top
Mutation of specific human genes subverts normal cellular physiology creating characteristic alterations called ‘hallmarks’ that fuel the development of cancer. The underlying processes that alter cellular pathways and gene function will be discussed. Cancer models and molecular therapies will be related to the cancer hallmarks.
Antirequisite(s): Pathology 4450A.
Extra Information: 2 lecture hours
Cross-listed with Pathology 4450A.
Course Weight: 0.50
Return to top
The translation of cancer research discoveries into clinical practice, emphasizing critical thinking, research design, evaluation of data from the literature and ethics. Students will engage with community partners associated with cancer research, patient support and care, and will work on a team project relevant to the partners’ needs.
Prerequisite(s): Biochemistry 4450A.
Extra Information: 3 lecture/tutorial hours per week.
Course Weight: 0.50
Return to top
This course applies knowledge of biochemistry and molecular biology to the understanding of human diseases. Topics of current interest are used as examples to explore the molecular mechanisms by which disease states arise and how this knowledge can be used to design therapies.
Prerequisite(s): Biochemistry 3381A.
Extra Information: 2 lecture hours.
Course Weight: 0.50
Return to top
The major laboratory course for the Honours Specialization in Biochemistry and Honours Specialization modules combined with Biochemistry. Lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Antirequisite(s): Anatomy and Cell Biology 4480E, Chemical Biology 4500E, Medical Biophysics 4970E, Medical Sciences 4900F/G/Z, Microbiology and Immunology 4970E, Pathology 4980E, the former Pathology and Toxicology 4980E, the former Biochemistry 4485E.
Prerequisite(s): Biochemistry 3380G, Biochemistry 3381A and Biochemistry 3382A, with marks in each of at least 70%. Enrolment is limited, and is available only to students in Year 4 of Honours Specialization modules in Biochemistry, Biochemistry and Cell Biology, Biochemistry and Pathology of Human Disease, Biochemistry and Chemistry, Biochemistry of Infection and Immunity, Computational Biochemistry, and Medical Biophysics and Biochemistry. Students in the Honours Specialization in Biochemistry of Infection and Immunity may substitute one of Microbiology and Immunology 3610F, Microbiology and Immunology 3620G, with a minimum mark of 70% in lieu of Biochemistry 3380G as a prerequisite. Students in the Honours Specialization in Computational Biochemistry may substitute Biochemistry 3383F/G with a minimum mark of 70% in lieu of Biochemistry 3380G as a prerequisite.
Extra Information: 15 hours per week. Enrolment in this course is limited.
Course Weight: 1.50
Return to top
The major laboratory course for the Honours Specialization in Biochemistry and Cancer Biology. Lectures on safety, use of animals in research, scientific integrity; an independent cancer-related research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Antirequisite(s): Anatomy and Cell Biology 4480E, Biochemistry 4483E, Chemical Biology 4500E, Medical Biophysics 4970E, Medical Sciences 4900F/G/Z, Microbiology and Immunology 4970E, Pathology 4980E, the former Pathology and Toxicology 4980E.
Prerequisite(s): A mark of at least 70% in one of the following: Biochemistry 3380G, Microbiology and Immunology 3620G, Physiology and Pharmacology 3000E or the former Pharmacology 3580Z; and enrolment in Year 4 of the Honours Specialization in Biochemistry and Cancer Biology.
Extra Information: 15 hours per week, indicate lecture/tutorial/lab hours.
To be offered for the first time in 2018/19.
Course Weight: 1.50
Return to top
This laboratory course is intended for students interested in pursuing graduate-level research. Lectures on literature searches, data mining, and effective communication; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (introduction to topic, mid-year report, seminar).
Prerequisite(s): One of Biochemistry 4483E, Biochemistry 4486E, or the former Biochemistry 4485E, and permission of the department.
Extra Information: 12 laboratory hours per week and participation in the Biochemistry Graduate Seminar.